Increasing Adherence in a Center-based Trial of Lifestyle Intervention in Older Individuals: U.s. Pointer Trial
Year: 2018
Type: conference-abstract
Abstract: Older individuals face barriers to participating in center-based clinical trials, including logistical and health issues that lessen adherence. The Alzheimer’s Association U.S. POINTER study is a multicenter trial (N=2,500) of individuals at increased risk for cognitive decline (60–79 years, sedentary lifestyle, poor diet, suboptimum cardiovascular and metabolic health status, parental history of significant memory impairment). It contrasts two lifestyle interventions, delivered at local YMCAs and Association chapters and differing in level of support, to encourage active lifestyles, healthy diets, social and intellectual engagement, and risk factor management. Recruitment through clinical trial networks begins with data-mining medical records to cull ineligible individuals and target those living proximal to intervention and data collection sites. Intervention protocols accommodate health events that compromise adherence. We report recruitment yields and describe data-mining algorithms tailored to enhance yields, protocols to enhance intervention adherence and heighten rigor, and approaches to trial design that promote dissemination and reproducibility.
Source: Innovation in Aging
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,977
OpenAlex ID: W2900415978