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First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal

Year: 2018
Type: article
Study design: Case Report
Abstract: Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.
Source: Antibiotics
DOI: 10.3390/antibiotics7040096
Authors: Cátia Caneiras, Filipa Calisto, Gabriela Jorge da Silva, Luis Lito, José Melo-Cristino, Aida Duarte
Institutions: University of Lisbon, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, University of Coimbra, Centro Hospitalar Lisboa Norte, Instituto de Medicina Molecular João Lobo Antunes
Language: English
Open Access status: gold
Estimated APC paid: $3,499
OpenAlex ID: W2900436101
FWCI: 1.003
Cites: 55
Cited by: 30
Related to: 10