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Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids

Year: 2018
Type: review
Abstract: Stem cell-derived brain organoids provide a powerful platform for systematic studies of tissue functional architecture and the development of personalized therapies. Here, we review key advances at the interface of soft matter and stem cell biology on synthetic alternatives to extracellular matrices. We emphasize recent biomaterial-based strategies that have been proven advantageous towards optimizing organoid growth and controlling the geometrical, biomechanical, and biochemical properties of the organoid's three-dimensional environment. We highlight systems that have the potential to increase the translational value of region-specific brain organoid models suitable for different types of manipulations and high-throughput applications.
DOI: 10.1063/1.5045124
Authors: Mariana Oksdath, Sally L. Perrin, Cedric Bardy, Emily F. Hilder, Cole A. DeForest, R. Dario Arrua, Guillermo A. Gomez
Institutions: South Australia Pathology, University of South Australia, Centre for Cancer Biology, Flinders University, South Australian Health and Medical Research Institute, University of Washington
Language: English
Open Access status: gold
Estimated APC paid: $2,200
Funders: National Science Foundation, Flinders University, University of South Australia, Cure Brain Cancer Foundation, Australian Research Council, National Health and Medical Research Council, National Medical Research Council
OpenAlex ID: W2900575301
FWCI: 0.629
Cites: 159
Cited by: 59
Related to: 10