Year: 2018
Type: article
Abstract: OBJECTIVE: Bipolar disorder has a wide range of clinical manifestations which may progress over time. The aim of this study was to test the applicability of a clinical staging model for bipolar disorder and to gain insight into the nature of the variables influencing progression through consecutive stages. METHODS: Using retrospectively reported longitudinal life chart data of 99 subjects from the Stanley Foundation Bipolar Network Naturalistic Follow-up Study, the occurrence, duration and timely sequence of stages 2-4 were determined per month. A multi-state model was used to calculate progression rates and identify determinants of illness progression. Stages 0, 1 and several other variables were added to the multi-state model to determine their influence on the progression rates. RESULTS: Five years after onset of BD (stage 2), 72% reached stage 3 (recurrent episodes) and 21% had reached stage 4 (continuous episodes), of whom 8% recovered back to stage 3. The progression from stage 2 to 3 was increased by a biphasic onset for both the depression-mania and the mania-depression course and by male sex. CONCLUSIONS: Staging is a useful model to determine illness progression in longitudinal life chart data. Variables influencing transition rates were successfully identified.
Source: Bipolar Disorders
DOI: 10.1111/bdi.12727
Institutions: Amsterdam Public Health, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam Neuroscience, University Medical Center Groningen, University of Groningen, George Washington University, University of California, Los Angeles, VA West Los Angeles Medical Center, VA Greater Los Angeles Healthcare System, Mayo Clinic, Klinikum am Weissenhof, Paracelsus Medizinische Privatuniversität, Lindner Center of HOPE, University of Cincinnati, University of Cincinnati Medical Center, VA Palo Alto Health Care System, Stanford Medicine, Stanford University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,730
OpenAlex ID: W2900630873