Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure
Year: 2018
Type: article
Study design: Observational Study
Abstract: The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability.
Source: Nature Communications
Authors: Alessia Visconti, David L. Duffy, Fan Liu, Gu Zhu, Wenting Wu, Yan Chen, Pirro G. Hysi, Changqing Zeng, Marianna Sanna, Mark M. Iles, Peter A. Kanetsky, Florence Demenais, Merel A. Hamer, Andre G. Uitterlinden, M. Arfan Ikram, Tamar Nijsten, Nicholas G. Martin, Manfred Kayser, Tim D. Spector, Jiali Han, Veronique Bataille, Mario Falchi
Institutions: King's College London, QIMR Berghofer Medical Research Institute, Chinese Academy of Sciences, Beijing Institute of Genomics, Erasmus MC, University of Chinese Academy of Sciences, Indiana University Indianapolis, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, University of Leeds, Moffitt Cancer Center, Inserm, Sorbonne Paris Cité, Université Paris Diderot, Institut Universitaire d'Hématologie, Brigham and Women's Hospital, West Hertfordshire Hospitals NHS Trust
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,714
Funders: Wellcome Trust, QIMR Berghofer Medical Research Institute, National Institute for Health and Care Research, British Skin Foundation, King's College London, European Commission, National Natural Science Foundation of China, ZonMw, Erasmus Universiteit Rotterdam, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, National Institutes of Health, Medical Research Council, National Health and Medical Research Council, National Cancer Institute
Awards: G1344543532, G1649060075, Biochemical Markers in the nurses' Health Study Cohort, G1718233269, G2028581175, NIHR Senior Investigator Award, G2906079785, G3184274510, G3576958170, Genetics of ageing: the genetic and environmental determinants of ageing in women., G3964026636, Dietary and Hormonal Determinants of Cancer in Women, G4353734806, G459566519, G4928916967, G4964662507, G511484510, G5121713029, G5520316217, G6035964259, G6144205333, G640459779, G6727411954, Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study, Genetics of ageing: the genetic and environmental determinants of ageing in women., G7724311201, NIHR Senior Investigator Award, Cancer Epidemiology Cohort in Male Health Professionals, G8065071721, G8443806426, G9000019617, G9000028950, G9000122174, G9000190097, Cancer Epidemiology Cohort in Male Health Professionals
OpenAlex ID: W2799394553