Inflammation and endothelial activation in early adulthood are associated with future emphysema: the CARDIA Lung Study
Year: 2018
Type: article
Study design: Observational Study
Abstract: Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome that is characterised by inflammation, airflow limitation and emphysema [1]. Systemic inflammation is associated with decreased lung function and an accelerated decline in lung function over time [2–4], and it has been postulated that chronic inflammation accelerates pulmonary structural damage. In addition to systemic inflammation, differences in cell adhesion molecules, which are markers of endothelial activation, have been tied to accelerated progression of emphysema on computed tomography (CT) in a large community population [5]. However, whether endothelial activation or systemic inflammation predicts the development of emphysema remains unclear. We hypothesised that elevated circulating levels of high-sensitivity C-reactive protein (hs-CRP), fibrinogen, and the cellular adhesion molecules intercellular adhesion molecule (ICAM)-1 and P-selectin, measured in early adulthood, are associated with emphysema on CT in middle age in a general population-based sample. Circulating markers of inflammation and endothelial activation predict future emphysema in a sample of generally healthy young adults
Source: European Respiratory Journal
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Cystic Fibrosis Foundation, AstraZeneca, GlaxoSmithKline, Brigham and Women's Hospital, Gilead Sciences, Biogen, Kaiser Permanente, Northwestern University, University of Minnesota, University of Alabama at Birmingham, Boston Scientific Corporation, Regeneron Pharmaceuticals, University of Alabama, Mereo BioPharma, National Institutes of Health, Genentech, Kaiser Foundation Research Institute, Feinberg School of Medicine, National Heart, Lung, and Blood Institute, Janssen Pharmaceuticals
Awards: G1220445869, G128745896, G1359416556, G1670764805, The Role of PGP in COPD-associated Pulmonary Hypertension, G1844203612, G1886881331, G190379715, G19438214, G2079069761, G2168236136, G2188224635, G228913406, G2691185462, G3167347955, G3248120388, G3541419165, G3853170735, G3901643820, G394051101, G429397448, G434728927, G5030101691, G5185723337, G5241320476, G5315814723, G5450057682, G5689420725, G5854587423, G6182174406, G640430542, G6530604611, G666720426, G7137698906, G739565590, G7588346739, G768957969, G8025105279, G814392139, G836417160, G84345693, G8670588822, G8954174134
OpenAlex ID: W2901165208