Multifunctional Coatings and Nanotopographies: Toward Cell Instructive and Antibacterial Implants
Year: 2018
Type: review
Abstract: In biomaterials science, it is nowadays well accepted that improving the biointegration of dental and orthopedic implants with surrounding tissues is a major goal. However, implant surfaces that support osteointegration may also favor colonization of bacterial cells. Infection of biomaterials and subsequent biofilm formation can have devastating effects and reduce patient quality of life, representing an emerging concern in healthcare. Conversely, efforts toward inhibiting bacterial colonization may impair biomaterial-tissue integration. Therefore, to improve the long-term success of medical implants, biomaterial surfaces should ideally discourage the attachment of bacteria without affecting eukaryotic cell functions. However, most current strategies seldom investigate a combined goal. This work reviews recent strategies of surface modification to simultaneously address implant biointegration while mitigating bacterial infections. To this end, two emerging solutions are considered, multifunctional chemical coatings and nanotopographical features.
Source: Advanced Healthcare Materials
Authors: Carlos Mas‐Moruno, Bo Su, Matthew J. Dalby
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,880
Awards: Micro- and nano-patterning of titanium surfaces for optimal osseointegration of orthopaedic implants, Nanoniche - The use of microRNAs and nanotopography to modulate skeletal stem cell fate and function, Multiscale topographical modulation of cells and bacteria for next generation orthopaedic implants, Multiscale topographical modulation of cells and bacteria for next generation orthopaedic implants., Novel antimicrobial surfaces to combat AMR infections in medical implants and devices, In vitro and in vivo studies of 3D orthopaedic implants with cell-instructive nanotopographies, BristolBridge: Bridging the Gaps between the Engineering and Physical Sciences and Antimicrobial Resistance, Micro- and nano-patterning of titanium surfaces for optimal osseointegration of orthopaedic implants, Development of new biofunctionalized materials for application in regenerative medicine, G987139097, G991129463
OpenAlex ID: W2901224488