Year: 2017
Type: dissertation
Abstract: Genome-scale network reconstructions serve as an ideal tool for the modeling of large, complex metabolic networks.In this study we use flux-balance analysis to investigate key amino acid dependencies of Plasmodium falciparum growth.Our model was able to produce a realistic flux distribution geared for the optimal production of biomass.We were able to simulate parasite growth in a variety of conditions and assess the favourability of these conditions for optimal growth.To demonstrate the applicability of the model we additionally simulate the response of the model to the introduction of an antimalarial agent, atovaquone.
Author: Robert William Burger
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: National Research Foundation
Award: G5343157487
OpenAlex ID: W2901264140