Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Year: 2018
Type: article
Abstract: BACKGROUND: Neurological disorders are now the leading source of disability globally, and ageing is increasing the burden of neurodegenerative disorders, including Parkinson's disease. We aimed to determine the global burden of Parkinson's disease between 1990 and 2016 to identify trends and to enable appropriate public health, medical, and scientific responses. METHODS: Through a systematic analysis of epidemiological studies, we estimated global, regional, and country-specific prevalence and years of life lived with disability for Parkinson's disease from 1990 to 2016. We estimated the proportion of mild, moderate, and severe Parkinson's disease on the basis of studies that used the Hoehn and Yahr scale and assigned disability weights to each level. We jointly modelled prevalence and excess mortality risk in a natural history model to derive estimates of deaths due to Parkinson's disease. Death counts were multiplied by values from the Global Burden of Disease study's standard life expectancy to compute years of life lost. Disability-adjusted life-years (DALYs) were computed as the sum of years lived with disability and years of life lost. We also analysed results based on the Socio-demographic Index, a compound measure of income per capita, education, and fertility. FINDINGS: In 2016, 6·1 million (95% uncertainty interval [UI] 5·0-7·3) individuals had Parkinson's disease globally, compared with 2·5 million (2·0-3·0) in 1990. This increase was not solely due to increasing numbers of older people, because age-standardised prevalence rates increased by 21·7% (95% UI 18·1-25·3) over the same period (compared with an increase of 74·3%, 95% UI 69·2-79·6, for crude prevalence rates). Parkinson's disease caused 3·2 million (95% UI 2·6-4·0) DALYs and 211 296 deaths (95% UI 167 771-265 160) in 2016. The male-to-female ratios of age-standardised prevalence rates were similar in 2016 (1·40, 95% UI 1·36-1·43) and 1990 (1·37, 1·34-1·40). From 1990 to 2016, age-standardised prevalence, DALY rates, and death rates increased for all global burden of disease regions except for southern Latin America, eastern Europe, and Oceania. In addition, age-standardised DALY rates generally increased across the Socio-demographic Index. INTERPRETATION: Over the past generation, the global burden of Parkinson's disease has more than doubled as a result of increasing numbers of older people, with potential contributions from longer disease duration and environmental factors. Demographic and potentially other factors are poised to increase the future burden of Parkinson's disease substantially. FUNDING: Bill & Melinda Gates Foundation.
Source: The Lancet Neurology
Authors: E. Ray Dorsey, Alexis Elbaz, Emma Nichols, Nooshin Abbasi, Foad Abd-Allah, Ahmed Abdelalim, Jose C. Adsuar, Mustafa Geleto Ansha, Carol Brayne, Jee-Young J Choi, Daniel Collado-Mateo, Nabila Dahodwala, Huyen Phuc Do, Dumessa Edessa, Matthias Endres, Seyed-Mohammad Fereshtehnejad, Kyle J Foreman, Fortune Gbetoho Gankpe, Rahul Gupta, Samer Hamidi, Graeme J. Hankey, Simon I. Hay, Mohamed I Hegazy, Desalegn T. Hibstu, Amir Kasaeian, Yousef Khader, Ibrahim Khalil, Young-Ho Khang, Yun Jin Kim, Yoshihiro Kokubo, Giancarlo Logroscino, João Massano, Norlinah Mohamed Ibrahim, Mohammed A. Mohammed, Alireza Mohammadi, Maziar Moradi-Lakeh, Mohsen Naghavi, Binh Thanh Nguyen, Yirga Legesse Nirayo, Felix Akpojene Ogbo, Mayowa Ojo Owolabi, David M. Pereira, Maarten J Postma, Mostafa Qorbani, Muhammad Aziz Rahman, Kedir T. Roba, Hosein Safari, Saeid Safiri, Maheswar Satpathy, Monika Sawhney, Azadeh Shafieesabet, Mekonnen Sisay Shiferaw, Mari Smith, Cassandra E I Szoeke, Rafael Tabarés-Seisdedos, Nu Thi Truong, Kingsley Nnanna Ukwaja, Narayanaswamy Venketasubramanian, Santos Villafaina, Kidu gidey weldegwergs, Ronny Westerman, Tissa Wijeratne, Andrea S. Winkler, Bach Tran Xuan, Naohiro Yonemoto, Valery L Feigin, Theo Vos, Christopher J L Murray
Institutions: University of Rochester, Inserm, Centre de recherche en Epidémiologie et Santé des Populations, Hôpital Paul-Brousse, Xiamen University Malaysia, Seoul National University, Jordan University of Science and Technology, Universidade do Porto, University of Washington, University Kebangsaan Malaysia Medical Centre, Institute for Health Metrics and Evaluation, National Cerebral and Cardiovascular Center, Jigjiga University, Rede de Química e Tecnologia, LAQV Requimte, University of Bari Aldo Moro, National University of Malaysia, Baqiyatallah University of Medical Sciences, The University of Sydney, Iran University of Medical Sciences, Western Sydney University, Mekelle University, Duy Tan University, Universidad de Extremadura, Cairo University, University of Rochester Medicine, University Medical Center Groningen, University of Groningen, University of Ibadan
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,782
Funders: Bill and Melinda Gates Foundation, Alzheimer's Association, Auckland University of Technology, New Zealand, Maragheh University of Medical Sciences, York University, National Institute for Health and Care Research, La Trobe University, National University of Singapore, Deakin University, Universitat de València, Ahvaz Jundishapur University of Medical Sciences, Universitetet i Oslo, Technische Universität München, H. Lundbeck A/S
OpenAlex ID: W2901519529