Population‐based birth defects data in the United States, 2011–2015: A focus on eye and ear defects
Year: 2018
Type: article
Study design: Observational Study
Abstract: BACKGROUND/OBJECTIVES: In this data brief, we examine major eye and ear anomalies (anophthalmia/microphthalmia, anotia/microtia, and congenital cataract) for a recent 5-year birth cohort using data from 30 population-based birth defects surveillance programs in the United States. METHODS: As a special call for data for the 2018 NBDPN Annual Report, state programs reported expanded data on eye/ear anomalies for birth years 2011-2015. We calculated the combined overall prevalence (per 10,000 live births) and 95% confidence intervals (CI), for the three anomalies as well as by maternal age, maternal race/ethnicity, infant sex, laterality, presence/absence of other major birth defects, and case ascertainment methodology utilized by the program (active vs. passive). RESULTS: The overall prevalence estimate (per 10,000 live births) was 1.5 (95% CI: 1.4-1.5) for anophthalmia/microphthalmia, 1.5 (95% CI: 1.4-1.6) for congenital cataract, and 1.8 (95% CI: 1.7-1.8) for anotia/microtia. Congenital cataract prevalence varied little by maternal race/ethnicity, infant sex, or case ascertainment methodology; prevalence differences were more apparent across strata for anophthalmia/microphthalmia and anotia/microtia. Prevalence among active vs. passive ascertainment programs was 50% higher for anophthalmia/microphthalmia (1.9 vs. 1.2) and two-fold higher for anotia/microtia (2.6 vs. 1.2). Anophthalmia/microphthalmia was more likely than other conditions to co-occur with other birth defects. All conditions were more frequent among older mothers (40+ years). CONCLUSIONS: This data brief provides recent prevalence estimates for anophthalmia/microphthalmia, congenital cataract, and anotia/microtia that address a data gap by examining pooled data from 30 population-based surveillance systems, covering a five-year birth cohort of about 12.4 million births.
Source: Birth Defects Research
DOI: 10.1002/bdr2.1413
Authors: Erin B. Stallings, Jennifer L. Isenburg, Cara T. Mai, Rebecca F. Liberman, Cynthia A. Moore, Mark A. Canfield, Jason L. Salemi, Russell S. Kirby, Tyiesha D. Short, Wendy N. Nembhard, Nina E. Forestieri, Dominique Heinke, C. J. Alverson, Paul A. Romitti, My‐Phuong Huynh, Lindsay E. Denson, Emily M. Judson, Philip J. Lupo, for the National Birth Defects Prevention Network
Institutions: Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, Massachusetts Department of Public Health, Texas Department of State Health Services, Baylor College of Medicine, University of South Florida, Oak Ridge Institute for Science and Education, Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, NC Department of Health and Human Services, North Carolina Division of Public Health, University of Iowa, Utah Department of Health, Utah Department of Health and Human Services, Oklahoma State Department of Health
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2901527611