Work

Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort

Year: 2018

Type: article

Abstract: Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms. Plasma and tissue levels of retinoic acid were not found to be causal. Human patients with alopecia attributed to fluconazole also underwent detailed assessment and in both our murine model and human cohort fluconazole induced telogen effluvium. Future work further examining the mechanism of fluconazole-induced alopecia should be undertaken.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01384-18

Authors: George R. Thompson, Charles R. Krois, Verena K. Affolter, Angela D. Everett, E. Katarina Varjonen, Victoria R. Sharon, Anil Singapuri, Michael Dennis, Ian McHardy, Hong Sik Yoo, Dawn M. Fedor, Nathan P. Wiederhold, Phylicia A. Aaron, Angie Gelli, Joseph L. Napoli, Stephen D. White

Institutions: University of California Davis Medical Center, University of California, Davis, University of California, Berkeley, Hofstra University, Donald & Barbara Zucker School of Medicine at Hofstra/Northwell, The University of Texas at San Antonio Health Science Center

Language: English

Topic: Hair Growth and Disorders

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of California, Davis, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G6762879375, Rdh10 and retinoic acid effects on differentiation

OpenAlex ID: W2901580671

FWCI: 0.881

Cites: 26

Cited by: 11

Related to: 10