Assembly of 809 whole mitochondrial genomes with clinical, imaging, and fluid biomarker phenotyping
Year: 2018
Type: article
Abstract: INTRODUCTION: Mitochondrial genetics are an important but largely neglected area of research in Alzheimer's disease. A major impediment is the lack of data sets. METHODS: We used an innovative, rigorous approach, combining several existing tools with our own, to accurately assemble and call variants in 809 whole mitochondrial genomes. RESULTS: To help address this impediment, we prepared a data set that consists of 809 complete and annotated mitochondrial genomes with samples from the Alzheimer's Disease Neuroimaging Initiative. These whole mitochondrial genomes include rich phenotyping, such as clinical, fluid biomarker, and imaging data, all of which is available through the Alzheimer's Disease Neuroimaging Initiative website. Genomes are cleaned, annotated, and prepared for analysis. DISCUSSION: These data provide an important resource for investigating the impact of mitochondrial genetic variation on risk for Alzheimer's disease and other phenotypes that have been measured in the Alzheimer's Disease Neuroimaging Initiative samples.
Source: Alzheimer s & Dementia
Authors: Perry G. Ridge, Mark E. Wadsworth, Justin B. Miller, Andrew J. Saykin, Robert C. Green, the Alzheimer's Disease Neuroimaging Initiative, John S.K. Kauwe
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
Funders: U.S. Department of Defense, Foundation for the National Institutes of Health, Alzheimer's Association, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, Biogen, University of Southern California, Brigham Young University, F. Hoffmann-La Roche, Meso Scale Diagnostics, Alzheimer's Disease Neuroimaging Initiative, BioClinica, Novartis Pharmaceuticals Corporation, Northern California Institute for Research and Education, Eisai, Servier, H. Lundbeck A/S, IXICO, National Institutes of Health, Genentech, Canadian Institutes of Health Research, National Institute on Aging, National Human Genome Research Institute, National Institute of Biomedical Imaging and Bioengineering, U.S. National Library of Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1012222616, G104586243, Risk Evaluation and Education for Alzheimer's Disease (REVEAL IV), G1298807586, Indiana Alzheimer Disease Center, Bioinformatics Strategies for Multidimensional Brain Imaging Genetics, G1554142629, G1593117279, Pleiotropic and Interaction Effects on Alzheimer's disease Risk and Progression, G1650819308, G1823308732, G1880935189, Alzheimer's Disease Neuroimaging Initiative, G2100670906, G2105457377, G2152643862, Epidemiology of Alzheimer’s disease resilience and risk pedigrees, G2189010064, G2340207221, G2423387114, G2471646051, G2522063444, G2835601961, G29951154, G3008982885, G3130427885, G3131374986, G3146424788, G3216574877, G3553156159, G3705772492, G3710456697, G3752451908, Impact of Disclosing Amyloid Imaging Results to Cognitively Normal Individuals, G3870774570, G3908963977, G3966393351, G4119534169, G43180419, G4401988282, G4475667458, G4501223628, G4800177743, G4860885537, Genome Sequence-Based Screening for Childhood Risk and Newborn Illness, G5207404921, G5209990037, G528601746, G5324093878, G5365730499, EFFECTS OF TRAUMATIC BRAIN INJURY (TBI) AND POST TRAUMATIC STRESS DISORDER (PTSD) ON ALZHEIMER'S DISEASE (AD) IN VETERANS USING IMAGING AND BIOMARKERS IN THE AD NEUROIMAGING INITIATIVE (ADNI)", G5389965057, G5654639750, G5740349702, G5850682332, G613619302, G6173816828, G6210868510, G6371410416, G6412110892, G6447063303, G6719828067, G6792506723, G6899163935, G6948409098, G72415811, G7298697282, G7414321945, Memory Circuitry in MCI and Early Alzheimerâs Disease Prodrome: Molecular Drivers, G764699806, G7799614282, G781725486, G8078485881, G8228018387, G8281378126, G839208290, G8852128998, G8895907669, G8897063270, Integration of Whole Genome Sequencing into Clinical Medicine, G8957659042, G9000005333, G9000031645, G9000039018, G9000061456, G9000072550, G9000074849, G9000120983, G9000122335, G9000186536, G9000245940, G9000330324, National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), G920654007
OpenAlex ID: W2781495400