Work

Interplay of Nitric Oxide Synthase (NOS) and SrrAB in Modulation of Staphylococcus aureus Metabolism and Virulence

Year: 2018

Type: article

Abstract: Staphylococcus aureus nitric oxide synthase (saNOS) is a major contributor to virulence, stress resistance, and physiology, yet the specific mechanism(s) by which saNOS intersects with other known regulatory circuits is largely unknown. The SrrAB two-component system, which modulates gene expression in response to the reduced state of respiratory menaquinones, is a positive regulator of nos expression.

Source: Infection and Immunity

Authors: Kimberly L. James, Austin B. Mogen, Jessica N. Brandwein, Silvia S. Orsini, Miranda J. Ridder, Mary A. Markiewicz, Jeffrey L. Bose, Kelly C. Rice

Institutions: University of Florida, Institute of Food and Agricultural Sciences, University of Kansas Medical Center

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1841233871, G3913702041, Southeast Resource Center for Integrated Metabolomics (SECIM), G9000114972, G9000349749

OpenAlex ID: W2901831373

FWCI: 1.527

Cites: 56

Cited by: 26

Related to: 10