Work

Preexposure to Isavuconazole Increases the Virulence of Mucorales but Not Aspergillus fumigatus in a Drosophila melanogaster Infection Model

Year: 2018

Type: article

Abstract: Breakthrough mucormycosis in patients receiving isavuconazole prophylaxis or therapy has been reported. We compared the impact of isavuconazole and voriconazole exposure on the virulence of clinical isolates of Aspergillus fumigatus and different Mucorales species in a Drosophila melanogaster infection model.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01896-18

Authors: Sebastian Wurster, Russell E. Lewis, Nathaniel D. Albert, Dimitrios P. Kontoyiannis

Institutions: The University of Texas MD Anderson Cancer Center, IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola, University of Bologna

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Astellas Pharma Global Development