Work

Acquired mechanisms of immune escape in cancer following immunotherapy

Year: 2018

Type: article

Abstract: Immunotherapy has revolutionized the management of numerous cancers; however, a substantial proportion that initially respond subsequently acquire means of immune escape and relapse. Analysis of recent clinical trials permits us to preliminarily understand how immunotherapies exert evolutionary pressures: selecting cancer subclones deficient in antigenicity and/or immunogenicity, thereby facilitating immune escape.

Source: Genome Medicine

DOI: 10.1186/s13073-018-0598-2

Authors: J. Bryan Iorgulescu, David Braun, Giacomo Oliveira, Derin B. Keskin, Catherine J. Wu

Institutions: Broad Institute, Brigham and Women's Hospital, Harvard University, Dana-Farber Cancer Institute

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,290