Work

Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation

Year: 2018

Type: review

Abstract: Immune protection and lasting memory are accomplished through the generation of phenotypically and functionally distinct CD8 T cell subsets. Understanding how these effector and memory T cells are formed is the first step in eventually manipulating the immune system for therapeutic benefit. In this review, we will summarize the current understanding of CD8 T cell differentiation upon acute infection, with a focus on the transcriptional and epigenetic regulation of cell fate decision and memory formation. Moreover, we will highlight the importance of high throughput sequencing approaches and single cell technologies in providing insight into genome-wide investigations and the heterogeneity of individual CD8 T cells.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2018.02826

Authors: Yao Chen, Ryan Zander, Achia Khatun, David M. Schauder, Weiguo Cui

Institutions: Medical College of Wisconsin, Versiti Blood Center of Wisconsin

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801