Work

Palladium-Catalyzed Chemoselective Protodecarboxylation of Polyenoic Acids

Year: 2018

Type: article

Abstract: Conditions for the first palladium-catalyzed chemoselective protodecarboxylation of polyenoic acids to give the desired polyenes in good yields are presented. The reactions proceed under mild conditions using either a Pd(0) or Pd(II) catalyst and tolerate a variety of aryl and aliphatic substitutions. Unique aspects of the reaction include the requirement of phosphines, water, and a polyene adjacent to the carboxylic acid.

Source: Organic Letters

DOI: 10.1021/acs.orglett.8b03016

Authors: Mohammed H. Al-Huniti, Mark A. Perez, Matthew K. Garr, Mitchell P. Croatt

Institution: University of North Carolina at Greensboro

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, North Carolina Biotechnology Center, University of North Carolina at Greensboro, Division of Chemistry

Awards: G6347570791, G7868968892