Work

Membrane estrogen receptor 1 is required for normal reproduction in male and female mice.

Year: 2017

Type: article

Abstract: evidence that membrane-initiated E2/ESR1 signaling is required for normal male and female reproductive functions and fertility. Signaling mechanisms for membrane ESR1 (mESR1), as well as how mESR1 works with nESR1 to mediate estrogen effects, are still being established. We discuss some possible mechanisms by which mESR1 might facilitate nESR1 signaling, as well as the emerging evidence that mESR1 might be a major mediator of epigenetic effects of estrogens, which are potentially linked to various adult-onset pathologies.

Source: PubMed

Authors: Manjunatha K Nanjappa, Ana M Mesa, Sergei G Tevosian, Laura de Armas, Rex A Hess, Indrani C Bagchi, Paul S Cooke

Institutions: University of Florida, University of Illinois Urbana-Champaign

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Diabetes and Digestive and Kidney Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Role of Membrane Estrogen Receptor 1 in Uterine Epithelial Response to Estrogen, Estrogen receptor mediated reprogramming of prostate in BPH, Membrane estrogen receptor 1 mediation of epigenetic effects of estrogen

OpenAlex ID: W2902210690

FWCI: 0.182

Cites: 86

Cited by: 2

Related to: 10