Year: 2018
Type: review
Abstract: Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; however, new modalities of caspase-independent regulated cell death have been identified, including necroptosis, pyroptosis, and autophagic cell death. As an understanding of the cellular mechanisms that mediate regulated cell death continues to grow, there is increasing evidence that these pathways are implicated in the pathogenesis of many pulmonary disorders. This review summarizes our understanding of regulated cell death as it pertains to the pathogenesis of chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and pulmonary arterial hypertension.
Source: Annual Review of Physiology
Authors: Maor Sauler, Isabel S. Bazan, Patty J. Lee
Institution: Yale University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: TLR4-MEDIATED EPIGENETIC AND SENESCENCE MECHANISMS IN EMPHYSEMA, G2169336302, G3709482579, G3937518425, MIF and DNA repair in the emphysematous lung, G5663565333, Training in Translational Lung Biology and Pathobiology, G7103068956, G7508365037, TLR4-Mediated Mechanisms of Lung Aging, G9000159461
OpenAlex ID: W2902352533