Work

Coregulatory long non-coding RNA and protein-coding genes in serum starved cells

Year: 2018

Type: article

Abstract: Serum starvation is widely used in cell biology to trigger cell cycle arrest, apoptosis, autophagy, and metabolic adaptations. Serum starvation-related molecular events have been well characterized at protein level but not at transcript level: how long non-coding RNAs contribute to the regulation of protein-coding genes is largely unknown. Here, we captured the lncRNA transcriptome in serum starved mouse embryonic fibroblasts and identified three main modes of action: cis-acting/coregulatory, trans-acting, and "miRNA-carrier". Whole-genome and individual gene level analyses support that our annotation provides an important platform for understanding lncRNA/protein-coding gene coregulatory mechanisms in serum starvation.

Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

DOI: 10.1016/j.bbagrm.2018.11.004

Authors: Fan Wang, Rui Liang, Benjamin Soibam, Jin Yang, Yu Liu

Institutions: First Affiliated Hospital of Xi'an Jiaotong University, University of Houston, University of Houston - Downtown

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,840