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The Power of Classic Music to Reduce Anxiety in Rats Treated with Simvastatin

Year: 2011

Type: article

Abstract: Introduction: This study was designed to investigate the effects of music in Wistar rats after sub-chronic treatment of simvastatin. The rats were orally administered with either simvastatin or saline (controls). After 4 weeks of drug treatment, the rats were selected for behavioral studies. The rats were exposed to music 24 hours before behavioral tests (Mozart’s piano sonata, KV361, Largo). Results: The experiments suggest that exposure to chronic treatment with simvastatin (1 or 10 mg/kg/day) reduced anxiety levels in rats when associated with Mozart music in an elevated plus-maze. Discussion: These results indicate that music can serve as an effective adjuvant in rats treated with simvastatin, and that this species could potentially be used in other preclinical models utilizing musical interventions. Methods:

Source: DOAJ (DOAJ: Directory of Open Access Journals)

Authors: Da Cruz Julia Niehues, De Lima Daniela Delwing, Dal Magro Debora Delwing, Da Cruz Jose Geraldo Pereira

Institutions: Universidade do Extremo Sul Catarinense, Universidade da Região de Joinville, Universidade Regional de Blumenau

Language: English

Topic: Music Therapy and Health

Subfield: Social Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2902782360

FWCI: 1.103

Cites: 37

Cited by: 11

Related to: 10