Year: 2018
Type: article
Abstract: The LG/J x SM/J advanced intercross line of mice (LG x SM AIL) is a multigenerational outbred population. High minor allele frequencies, a simple genetic background, and the fully sequenced LG and SM genomes make it a powerful population for genome-wide association studies. Here we use 1,063 AIL mice to identify 126 significant associations for 50 traits relevant to human health and disease. We also identify thousands of cis- and trans-eQTLs in the hippocampus, striatum, and prefrontal cortex of ~200 mice. We replicate an association between locomotor activity and Csmd1, which we identified in an earlier generation of this AIL, and show that Csmd1 mutant mice recapitulate the locomotor phenotype. Our results demonstrate the utility of the LG x SM AIL as a mapping population, identify numerous novel associations, and shed light on the genetic architecture of mammalian behavior.
Source: Nature Communications
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,990
Funders: University of Chicago, Washington University in St. Louis, University of Aberdeen, National Institutes of Health, Directorate for Biological Sciences, University of California, San Diego, National Institute on Drug Abuse, National Human Genome Research Institute, National Institute of General Medical Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: Medical Scientist National Research Service Award, Methods for Human Genetic Mapping, Genetic Variation of Muscle Mass, Methods for Complex Trait Mapping in Isolated Populations, Genetics and Regulation, Systems Genetic Analysis of Methamphetamine's Motivational Effects in a Mouse AIL, G8908545868
OpenAlex ID: W2903375254