Work

PSMB5 plays a dual role in cancer development and immunosuppression.

Year: 2017

Type: article

Abstract: . Furthermore, lentiviral delivery of PSMB5 shRNA significantly decreased tumor growth in a subcutaneous mouse model. In conclusion, our bioinformatics study and functional experiments revealed that PSMB5 served as novel cancer therapeutic targets. These results also demonstrated a novel translational approach to improve cancer immunotherapy.

Source: Europe PMC (PubMed Central)

Authors: Chih-Yang Wang, Chung-Yen Li, Hui-Ping Hsu, Chien-Yu Cho, Meng-Chi Yen, Tzu-Yang Weng, Wei-Ching Chen, Yu-Hsuan Hung, Kuo-Ting Lee, Jui-Hsiang Hung, Yi-Ling Chen, Ming-Derg Lai

Institutions: National Cheng Kung University, Kaohsiung Medical University, Kaohsiung Medical University Chung-Ho Memorial Hospital, Chia Nan University of Pharmacy and Science

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2903708756

FWCI: 1.363

Cites: 57

Cited by: 60

Related to: 10