Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition
Year: 2018
Type: article
Study design: Observational Study
Abstract: The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis.
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kwy259
Authors: Laura Costas, Leila Lujan-Barroso, Yolanda Benavente, Naomi E Allen, Pilar Amiano, Eva Ardanaz, Caroline Besson, Heiner Boeing, Bas Bueno-de-Mesquita, Iris Cervenka, Renée T Fortner, Agnès Fournier, Marc Gunter, Sophia Harlid, José María Huerta, Mats Jerkeman, Karin Jirström, Rudolf Kaaks, Anna Karakatsani, Kay-Tee Khaw, Anastasia Kotanidou, Eiliv Lund, Giovanna Masala, Amalia Mattiello, Beatrice Melin, Virginia Menéndez, Neil Murphy, Alexandra Nieters, Kim Overvad, Elio Riboli, Carlotta Sacerdote, Maria-Jose Sánchez, Julie A Schmidt, Sabina Sieri, Anne Tjønneland, Antonia Trichopoulou, Rosario Tumino, Roel Vermeulen, Elisabete Weiderpass, Silvia de Sanjosé, Antonio Agudo, Delphine Casabonne
Institutions: Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universitat de Barcelona, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, University of Oxford, Biogipuzkoa Health Research Institute, Instituto de Salud Pública de Navarra, Université Paris-Sud, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, Centre Hospitalier de Versailles, German Institute of Human Nutrition, University Medical Center Utrecht, University of Malaya, National Institute for Public Health and the Environment, Imperial College London, German Cancer Research Center, Centre international de recherche sur le cancer, Umeå University, Instituto Murciano de Investigación Biosanitaria, Lund University, National and Kapodistrian University of Athens, Hellenic Health Foundation, University General Hospital Attikon, University of Cambridge, Evangelismos Hospital, UiT The Arctic University of Norway, Federico II University Hospital, University of Naples Federico II, Gobierno del Principado de Asturias, University of Freiburg, University Medical Center Freiburg, Aarhus University, Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, University of Turin, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Andalusian School of Public Health, Fondazione IRCCS Istituto Nazionale dei Tumori, Danish Cancer Society, Utrecht University, University of Helsinki, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, Program for Appropriate Technology in Health
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: World Health Organization, Aarhus Universitet, Helsingin Yliopisto, Kræftens Bekæmpelse, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Cancer Research UK, Imperial College London, University of Oxford, European Commission, Institut National de la Santé et de la Recherche Médicale, Universiteit Utrecht, Bundesministerium für Bildung und Forschung, Albert-Ludwigs-Universität Freiburg, Cancerfonden, Lunds Universitet, Karolinska Institutet, Ligue Contre le Cancer, Vetenskapsrådet, Universiti Malaya, KWF Kankerbestrijding, Samfundet Folkhälsan, Umeå Universitet, Associazione Italiana per la Ricerca sul Cancro, National and Kapodistrian University of Athens, Universitat de Barcelona, Deutsche Krebshilfe, Universidad de Granada, Université Paris-Saclay, Université Paris-Sud, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Hellenic Health Foundation, Université de Versailles Saint-Quentin-en-Yvelines, Medical Research Council, World Cancer Research Fund, Medicinska Fakulteten, Lunds Universitet, Medicinska fakulteten, Umeå Universitet, School of Public Health, Imperial College London
Awards: G1055973116, G1192877484, G1265254713, G1344656563, G1532219801, G1767199718, G1788645866, G2131326840, G2149865848, G2216207056, G2235605558, G2257231888, G2372467518, G2539064604, G2572521044, G2657122180, G2742323354, G29072894, G3077395769, G3084320185, G3216658785, G3544161537, G3675143906, G3747421453, G382879149, G3980646122, G4049848471, G4201735853, G4213141252, G4303038735, G43956866, Health of vegetarians, G459595259, G4682079261, G4752739612, G4811780622, G4884057766, G490534113, G5406065712, G558017500, G5897142711, G5990830295, G6085534252, G6231161894, G6442500046, G6723261869, G6779186093, G6820515600, G7025202487, G7306252069, G7426181285, G7447125227, G7600088736, G7646326732, G8050896463, G8279237360, G8407261631, G8525262851, G8869854444, G8959392569, G8978728421
OpenAlex ID: W2903775650