Work

Macropinocytosis and autophagy crosstalk in nutrient scavenging

Year: 2018

Type: article

Abstract: Adaptive strategies used by cells to scavenge and recycle essential nutrients are important for survival in nutrient-depleted environments such as cancer tissues. Autophagy and macropinocytosis are two major mechanisms that promote nutrient recycling and scavenging, which share considerable, yet poorly understood, cross-regulation. Here we review recent findings that connect these starvation response mechanisms and discuss the implications of their crosstalk. This article is part of the Theo Murphy meeting issue 'Macropinocytosis'.

Source: Philosophical Transactions of the Royal Society B Biological Sciences

DOI: 10.1098/rstb.2018.0154

Authors: Oliver Florey, Michael Overholtzer

Institutions: Babraham Institute, Memorial Sloan Kettering Cancer Center

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Cancer Research UK, Biotechnology and Biological Sciences Research Council, National Cancer Institute