Work

The Role of the Phosphorus Atom in Drug Design

Year: 2018

Type: review

Abstract: Although the phosphorus atom is found in a variety of oxidation states, most of the phosphorus-containing molecules of pharmacological importance possess phosphorus in the form of phosphonate or phosphinate functional groups, or in a major oxidation state as a phosphate group. The most common occurrence of phosphorus in drugs is either in prodrugs or in compounds for which the phosphorus atom plays a role in the biological activity, such as in modified nucleotides, in metabolically stable analogues of metabolites bearing phosphate groups, and as bioisosteric analogues of carboxyl groups.

Source: ChemMedChem

DOI: 10.1002/cmdc.201800693

Authors: Juan B. Rodriguez, Carola Gallo‐Rodriguez

Institutions: Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Agencia Nacional de Promoción Científica y Tecnológica

Awards: Biosíntesis de isoprenoides como blanco molecular para el diseño de agentes antiparasitarios, G5612569928, G5984441898, G6066691657, G6688740137