Work

Regulation of Ribosome Biogenesis in Skeletal Muscle Hypertrophy

Year: 2018

Type: review

Abstract: The ribosome is the enzymatic macromolecular machine responsible for protein synthesis. The rates of protein synthesis are primarily dependent on translational efficiency and capacity. Ribosome biogenesis has emerged as an important regulator of skeletal muscle growth and maintenance by altering the translational capacity of the cell. Here, we provide evidence to support a central role for ribosome biogenesis in skeletal muscle growth during postnatal development and in response to resistance exercise training. Furthermore, we discuss the cellular signaling pathways regulating ribosome biogenesis, discuss how myonuclear accretion affects translational capacity, and explore future areas of investigation within the field.

Source: Physiology

DOI: 10.1152/physiol.00034.2018

Authors: Vandré Casagrande Figueiredo, John J. McCarthy

Institution: University of Kentucky

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: The effects of exercise on satellite cell dynamics during aging, Novel Roles for Satellite Cells in Adult Skeletal Muscle Adaptation, G6408700345, G8403884145