Work

Associations Between Genetic Data and Quantitative Assessment of Normal Facial Asymmetry

Year: 2018

Type: article

Abstract: Human facial asymmetry is due to a complex interaction of genetic and environmental factors. To identify genetic influences on facial asymmetry we developed a method for automated scoring that summarizes local morphology features and their spatial distribution. A genome-wide association study using asymmetry scores from two local symmetry features was conducted and significant genetic associations were identified for one asymmetry feature, including genes thought to play a role in craniofacial disorders and development: NFATC1, SOX5, NBAS, and TCF7L1. These results provide evidence that normal variation in facial asymmetry may be impacted by common genetic variants and further motivate the development of automated summaries of complex phenotypes.

Source: Frontiers in Genetics

DOI: 10.3389/fgene.2018.00659

Authors: Sara Rolfe, Su-In Lee, Linda Shapiro

Institutions: Seattle Children's Research Institute, University of Washington

Language: English

Topic: Morphological variations and asymmetry

Subfield: Geometry and Topology

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801