Work

Mechanisms of Chemoresistance in Tumor-Derived Cancer Stem Cells

Year: 2012

Type: article

Abstract: The existence of cancer stem cells (CSCs) has been already established in several hematopoietic and non-hematopoietic cancers. Chemoresistance has also been demonstrated as a major cause of cancer treatment failure. Although chemotherapy kills most cells in a tumor, it is believed to leave CSCs behind which might be an important mechanism of resistance and thereby cancer treatment failure. The quiescent nature and existence of adenosine triphosphate (ATP)-binding cassette (ABC) drug transporters in CSCs have been suggested to protect them from chemotherapeutic agents. Gaining a better insight into the mechanisms of CSCs chemoresistance might therefore lead to new therapeutic targets and development of better anticancer strategies. Keywords: Cancer stem cells, Chemotherapy, Drug resistance.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

Authors: Hamid Reza Mirzaei, Marjan Gharagozloo, Abbas Rezaei, Mohammad Soleimani, Hamid Kalantari, Hamed Mirzaei, Mohammad Eghbali, Mohsen Chamanara, Mohammadhasan Tajadini

Institutions: Isfahan University of Medical Sciences, Aja University of Medical Sciences, Karaj Payam Noor University, Payame Noor University

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2903963017

FWCI: 0.164

Cites: 84

Cited by: 2

Related to: 10