Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria
Year: 2018
Type: article
Abstract: nervous system, hTau expression reduced mitophagy, whereas hP301L expression completely inhibited it. These effects were not due to changes in the mitochondrial membrane potential or the cytoskeleton, as tau specifically impaired Parkin recruitment to defective mitochondria by sequestering it in the cytosol. This sequestration was mediated by aberrant interactions of Parkin with the projection domain of tau. As mitochondria are dysfunctional in neurodegenerative conditions, these data suggest a vicious cycle, with tau also inhibiting the degradation of damaged mitochondria.
Source: The EMBO Journal
Institutions: The University of Queensland, UNSW Sydney
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $7,990
Awards: Live molecular imaging using super resolution microscopy, two photon and spinning disk confocal microscopy, TAU AND ITS MASTER REGULATOR FYN IN NEURONS, Nuclear functions of the microtubule-associated protein tau, SELECTIVE VULNERABILITY IN ALZHEIMER’S DISEASE AND RELATED DISORDERS, G745835865, Frontotemporal dementia and motor neurodegenerative syndromes, Epigenetic determination of neuronal vulnerability and neurodegenerative disease
OpenAlex ID: W2903973081