Medication Exposure Patterns in Primary Care Patients Prescribed Pharmacogenetically Actionable Opioids
Year: 2018
Type: article
Abstract: Current approaches to assessing medication exposure fail to capture the complexity of the phenomenon and the context in which it occurs. This study's purpose was to develop a typology of subgroups of patients who share common patterns of medication exposure. To create the typology, we used an exemplar sample of 30 patients in a large public healthcare system who had been prescribed the pharmacogenetically actionable opioids codeine or tramadol. Data related to medication exposure were drawn from large data repositories. Using a person-oriented qualitative approach, eight subgroups of patients who shared common patterns of medication exposure were identified. The subgroups had one of five opioid prescription patterns (i.e., singular, episodic, switching, sustained, multiplex), and one of three types of primary foci of medical care (i.e., pain, comorbidities, both). The findings reveal medication exposure patterns that are dynamic, multidimensional, and complex, and the typology offers an innovative approach to assessing medication exposure.
Source: The Qualitative Report
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $500
Funders: Eli Lilly and Company, Indiana Clinical and Translational Sciences Institute, Lilly Endowment, National Institutes of Health, National Human Genome Research Institute, National Institute of Nursing Research, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: G1218922180, Indiana Clinical and Translational Sciences Institute, Indiana University: Training in Behavioral Nursing, EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT, G4954646042, Embedding Pharmacogenotyping in an Integrated Health System for the Underserved, G6223059496, G6875631655, G724942601, Targeting Research and Academic Training of Nurses in Genomics
OpenAlex ID: W2904109195