Work

Models of polymer physics for the architecture of the cell nucleus

Year: 2018

Type: review

Abstract: The depth and complexity of data now available on chromosome 3D architecture, derived by new technologies such as Hi-C, have triggered the development of models based on polymer physics to explain the observed patterns and the underlying molecular folding mechanisms. Here, we give an overview of some of the ideas and models from physics introduced to date, along with their progresses and limitations in the description of experimental data. In particular, we focus on the Strings&Binders and the Loop Extrusion model of chromatin architecture. This article is categorized under: Analytical and Computational Methods > Computational Methods.

Source: WIREs Systems Biology and Medicine

DOI: 10.1002/wsbm.1444

Authors: Andrea Esposito, Carlo Annunziatella, Simona Bianco, Andrea M. Chiariello, Luca Fiorillo, Mario Nicodemi