Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study
Year: 2018
Type: article
Study design: Observational Study
Abstract: Zinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplastic cells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studies is a conflicting one. Our aim was to explore this association in an MCC-Spain case-control study, considering tumor aggressiveness and extension, as well as genetic susceptibility to PC. 733 incident cases and 1228 population-based controls were included for this study. Dietary zinc was assessed using a food frequency questionnaire, and genetic susceptibility was assessed with a single nucleotide polymorphisms (SNP)-based polygenic risk score (PRS). The association between zinc intake and PC was evaluated with mixed logistic and multinomial regression models. They showed an increased risk of PC in those with higher intake of zinc (Odds Ratio (OR) tertile 3vs1: 1.39; 95% Confidence interval (CI):1.00⁻1.95). This association was mainly observed in low grade PC (Gleason = 6 RRR tertile 3vs1: 1.76; 95% CI:1.18⁻2.63) as well as in localized tumors (cT1-cT2a RRR tertile 3vs1: 1.40; 95% CI:1.00⁻1.95) and among those with higher PRS (OR tertile 3vs1: 1.50; 95% CI:0.89⁻2.53). In conclusion, a higher dietary zinc intake could increase the risk of low grade and localized tumors. Men with higher genetic susceptibility0020might also have a higher risk of PC associated with this nutrient intake.
Source: Nutrients
DOI: 10.3390/nu11010018
Authors: Enrique Gutiérrez-González, Adela Castelló, Pablo Fernández-Navarro, Gemma Castaño-Vinyals, Javier Llorca, Dolores Salas-Trejo, Inmaculada Salcedo-Bellido, Nuria Aragonés, Guillermo Fernández-Tardón, Juan Alguacil, Esther Gracia-Lavedan, Esther García-Esquinas, Inés Gómez-Acebo, Pilar Amiano, Dora Romaguera, Manolis Kogevinas, Marina Pollán, Beatriz Pérez-Gómez
Institutions: Instituto de Salud Carlos III, Escuela Nacional de Sanidad, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Universidad de Alcalá, Universitat Pompeu Fabra, Municipal Institute for Medical Research, Barcelona Institute for Global Health, Hospital del Mar Research Institute, Universidad de Cantabria, Instituto de Investigación Marqués de Valdecilla, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Universidad de Oviedo, Universidad de Huelva, Universidad Autónoma de Madrid, Biogipuzkoa Health Research Institute, Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Health Research Institute of the Balearic Islands, Hospital Universitario Son Espases
Language: English
Topic: Trace Elements in Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Funders: Fundación Bancaria Caja de Ahorros de Asturias, Ministerio de Economía y Competitividad, Generalitat Valenciana, Universidad de Oviedo, Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España, Junta de Andalucía, Fundación Marqués de Valdecilla, Instituto de Salud Carlos III, Conselleria de Sanitat Universal i Salut Pública
Awards: G1418927621, G1443676575, G1943266716, G2018771256, G2045172656, G2620658983, G2739777946, G3033981070, G3635063837, G3771020718, G4502495630, G451885579, G5754638915, G5893827543, G640610580, G6508629688, G7353086265, Integración de big data genéticos y datos clínicos: supervivencia y calidad de vida en participantes con cáncer de próstata en el estudio MCC-Spain, G8190793960, Las uñas de los pies como biomarcador de exposición:significado y relación con la incidencia de cáncer, G8759146715, G8835261403, G8931017233, G994301069
OpenAlex ID: W2904256426