Chemotherapy and diffuse low-grade gliomas: a survey within the European Low-Grade Glioma Network
Year: 2018
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Diffuse low-grade gliomas (DLGGs) are rare and incurable tumors. Whereas maximal safe, functional-based surgical resection is the first-line treatment, the timing and choice of further treatments (chemotherapy, radiation therapy, or combined treatments) remain controversial. METHODS: An online survey on the management of DLGG patients was sent to 28 expert centers from the European Low-Grade Glioma Network (ELGGN) in May 2015. It contained 40 specific questions addressing the modalities of use of chemotherapy in these patients. RESULTS: The survey demonstrated a significant heterogeneity in practice regarding the initial management of DLGG patients and the use of chemotherapy. Interestingly, radiation therapy combined with the procarbazine, CCNU (lomustine), and vincristine regimen has not imposed itself as the gold-standard treatment after surgery, despite the results of the Radiation Therapy Oncology Group 9802 study. Temozolomide is largely used as first-line treatment after surgical resection for high-risk DLGG patients, or at progression. CONCLUSIONS: The heterogeneity in the management of patients with DLGG demonstrates that many questions regarding the postoperative strategy and the use of chemotherapy remain unanswered. Our survey reveals a high recruitment potential within the ELGGN for retrospective or prospective studies to generate new data regarding these issues.
Source: Neuro-Oncology Practice
DOI: 10.1093/nop/npy051
Authors: Amélie Darlix, Emmanuel Mandonnet, Christian F Freyschlag, Daniel Pinggera, Marie-Therese Forster, Martin Voss, Joachim Steinbach, Carmel Loughrey, John Goodden, Giuseppe Banna, Concetta Di Blasi, Nicolas Foroglou, Andreas F Hottinger, Marie-Hélène Baron, Johan Pallud, Hugues Duffau, Geert-Jan Rutten, Fabien Almairac, Denys Fontaine, Luc Taillandier, Catarina Pessanha Viegas, Luisa Albuquerque, Gord von Campe, Tadeja Urbanic-Purkart, Marie Blonski
Institutions: Université de Montpellier, Hôpital Lariboisière, Innsbruck Medical University, Universität Innsbruck, University Hospital Frankfurt, Leeds General Infirmary, Ospedale Cannizzaro, Aristotle University of Thessaloniki, AHEPA University Hospital, Centre Hospitalier Universitaire Vaudois, Centre Hospitalier Universitaire de Besançon, Sorbonne Paris Cité, Centre Hospitalier Sainte-Anne, Université Paris Descartes, Inserm, Centre Hospitalier Universitaire de Montpellier, Centre for Psychiatry and Neuroscience, Elisabeth-TweeSteden Ziekenhuis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Régional et Universitaire de Nancy, Hospital Garcia de Orta, Medical University of Graz
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,036
OpenAlex ID: W2904737739