Work

Protective effects of plant‐derived natural products on renal complications

Year: 2018

Type: review

Abstract: Diabetic nephropathy is the leading cause of renal failure worldwide. This debilitating disorder has several underlying pathophysiologic mechanisms, and therefore a variety of pharmacologic agents have been developed to prevent or treat diabetic nephropathy; however, synthetic drugs may possess unfavorable side effects. In response to this, the global use of herbal-based pharmacologic agents is increasing among diabetic patients. Numerous studies have reported therapeutic benefits of herbal-based compounds against diabetes-induced renal dysfunction. These agents can prevent renal dysfunction and improve renal function by blocking or suppressing deleterious pathways such as oxidative stress, inflammation, apoptosis, necrosis, and nitric oxide deprivation that lead to vascular injuries. In the current study, we have reviewed the beneficial properties of the most common herbal agents used in renal complications and diabetic nephropathy.

Source: Journal of Cellular Physiology

DOI: 10.1002/jcp.27950

Authors: Habib Yaribeygi, Luis E. Simental‐Mendía, Alexandra E. Butler, Amirhossein Sahebkar

Institutions: Shahid Beheshti University, Shahid Beheshti University of Medical Sciences, Mexican Social Security Institute, Mashhad University of Medical Sciences

Language: English

Topic: Natural Antidiabetic Agents Studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2904762647

FWCI: 0.705

Cites: 167

Cited by: 46

Related to: 10