Prevalence of Pharmacogenomic Variants Affecting the Efficacy of Clopidogrel Therapy in the Hispanic Community Health Study/Study of Latinos Cohort
Year: 2018
Type: article
Abstract: PURPOSE: Although clopidogrel is the most widely used oral P2Y12 receptor antagonist, up to 10% of acute coronary syndrome patients treated with clopidogrel will experience a recurrent myocardial infarction and 2-3% will experience stent thrombosis within 1 year. The purpose of this research is to describe the prevalence of pharmacogene variants associated with clopidogrel responsiveness (CYP2C19, B4GALT2, ABCB1, PON1, CES1 and P2RY12) in Hispanic/Latino patients of diverse backgrounds. METHODS: Minor allele frequencies of nine variants from participants of Hispanic Community Health Study/Study of Latinos were compared between subpopulations as well as to continental ancestry references using z-test for independent proportions. RESULTS: MAFs for six out of nine variants differed between Caribbean and Mainland subpopulations (p < 0.05). Compared with European reference group, MAFs of ABCB1, CES1 and PON1 were higher in Hispanic Community Health Study/Study of Latinos, whereas B4GALT2 and CYP2C19*2 and *17 were lower. CONCLUSION: Significant differences in the prevalence of most pharmacogenomic variants related to clopidogrel response provide a foundation to better inform ongoing and future clinical studies of clopidogrel pharmacogenetics in the US Hispanic/Latino populations.
Source: Pharmacogenomics
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: University of Miami, Northwestern University, San Diego State University, National Institutes of Health, University of Illinois at Urbana-Champaign, Albert Einstein College of Medicine, Yeshiva University, University of Illinois at Chicago, National Heart, Lung, and Blood Institute, National Institute on Minority Health and Health Disparities
Awards: G1081972346, G1312369436, Hispanic Community Health Study, G1455175283, G1666450717, G1818487580, G1866572497, G1984718218, Hispanics in Research Capability: SoHP & SOM Partnership (HIREC), G215000922, G2466919156, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2528054427, G2644289446, G2651066328, G2970637568, G308844681, Hispanic Community Health Study, G3614733703, G432753757, Hispanic Community Health Study, G5015503974, G5102588038, G528357465, G5365244667, HISPANIC COMMUNITY HEALTH STUDY - COORDINATING CENTER, G543802643, G5785169696, G596642789, G6075306088, G6088185517, G6149955053, G7132511053, Hispanic Clinical and Translational Research Education and Career Development Program, G820454163, G8987601928, Center for Collaborative Research in Health Disparities, G937084196
OpenAlex ID: W2904841582