Year: 2018
Type: article
Abstract: Non-small cell lung cancer (NSCLC) represents about 85% of all lung cancer cases. Lung cancer is the most frequent non-AIDS-defining malignancies in HIV-infected patients. The mechanism of the increased risk for lung cancer in HIV-1 patients is poorly understood. HIV-1 Nef protein has been suggested to be one of the key players in HIV-related lung disease. In here, we showed the involvement of Nef protein in cell modifications such as fibroblasts (IMR-90) and normal (BEAS-2B) or cancerous (A549) epithelial cells. We demonstrated that Nef protein reprograms initial stages of lung cancer (e.g. changes in the metabolism, improved cell survival and invasion, increase the angiogenesis factor VEGF). Additionally, we showed that Nef is provoking a global decrease of mature miRNA and a decrease of DICER1 and AGO expression in lung cells. MiRNAs play a crucial role in cell signaling and homeostasis, functioning as oncogenes or tumor suppressors, and their dysregulation can contribute to the tumorigenic process. These results showed that HIV-1 Nef protein is directly involved in preventing cell death and contributes to tumor progression.
Source: Cell Cycle
Institution: Temple University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
Awards: PGC-1alpha and Reelin: new players in HAND progression., Involvement of HIV-1 Vpr in neuronal degeneration., G3071430007, Reactivation of embryonic growth programs in liver cancer, Role of p53 family in neuropathogenesis in AIDS, Role of microRNA in HIV associated neurological disorder (HAND)., Early Stage Training in the Neurosciences
OpenAlex ID: W2904847704