Work

Exosomes in chronic inflammatory skin diseases and skin tumors

Year: 2018

Type: review

Abstract: Exosomes are membrane vesicles of endocytic origin that can mediate communication between cells and the transport of cellular components such as microRNAs, mRNAs, proteins and DNA. Recently, exosomes have been under investigation for their significant roles in both healthy physiology and disease states. Herein, we review the role of exosomes in chronic inflammatory skin diseases and skin tumors, especially focusing on systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous pemphigoid and melanoma. Moreover, we emphasize the involvement of changes in exosome cargo in the regulation of these diseases.

Source: Experimental Dermatology

DOI: 10.1111/exd.13857

Authors: Wen‐Ming Wang, Chao Wu, Hong‐Zhong Jin

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Natural Science Foundation of China, Chinese Academy of Meteorological Sciences, Chinese Academy of Medical Sciences Initiative for Innovative Medicine