Work

Antiviral effects of selected nucleoside analogues against human parechoviruses A1 and A3

Year: 2018

Type: article

Abstract: Parechoviruses A (HPeV, Picornaviridae) are neglected human pathogens that cause sepsis-like illness and severe neurological complications in infants. There are no antivirals available for the treatment of HPeV infections. We here report on cell-based assays that allow for medium-throughput antiviral screening of compound libraries against HPeV. The nucleoside viral polymerase inhibitor 2'-C-methylcytidine was identified as being an in vitro replication inhibitor of HPeV1 and HPeV3 that can serve as a reference molecule for further antiviral studies.

Source: Antiviral Research

DOI: 10.1016/j.antiviral.2018.12.009

Authors: Kristina Lanko, Yipeng Ma, Leen Delang, Carmen Mirabelli, Johan Neyts

Institutions: Rega Institute for Medical Research, KU Leuven, University of Michigan

Language: English

Topic: Viral Infections and Immunology Research

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,160