Work

The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris

Year: 2018

Type: article

Abstract: Candida auris is an emerging pathogen associated with significant mortality and often multidrug resistance. VT-1598, a tetrazole-based fungal CYP51-specific inhibitor, was evaluated in vitro and in vivo against C. auris .

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02233-18

Authors: Nathan P. Wiederhold, Shawn R. Lockhart, Laura K. Najvar, Elizabeth L. Berkow, Rosie Jaramillo, Marcos Olivo, Edward P. Garvey, Christopher M. Yates, Robert J. Schotzinger, Gabriel Catano, Thomas F. Patterson

Institutions: The University of Texas at San Antonio Health Science Center, Centers for Disease Control and Prevention, South Texas Veterans Health Care System, Viamet Pharmaceuticals (United States)

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Allergy and Infectious Diseases

Awards: G1083524591, G4932309

OpenAlex ID: W2905319985

FWCI: 6.234

Cites: 28

Cited by: 79

Related to: 10