Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering
Year: 2018
Type: article
Abstract: The discovery of bioactive glasses (BGs) in the late 1960s by Larry Hench et al. was driven by the need for implant materials with an ability to bond to living tissues, which were intended to replace inert metal and plastic implants that were not well tolerated by the body. Among a number of tested compositions, the one that later became designated by the well-known trademark of 45S5 Bioglass® excelled in its ability to bond to bone and soft tissues. Bonding to living tissues was mediated through the formation of an interfacial bone-like hydroxyapatite layer when the bioglass was put in contact with biological fluids in vivo. This feature represented a remarkable milestone, and has inspired many other investigations aiming at further exploring the in vitro and in vivo performances of this and other related BG compositions. This paradigmatic example of a target-oriented research is certainly one of the most valuable contributions that one can learn from Larry Hench. Such a goal-oriented approach needs to be continuously stimulated, aiming at finding out better performing materials to overcome the limitations of the existing ones, including the 45S5 Bioglass®. Its well-known that its main limitations include: (i) the high pH environment that is created by its high sodium content could turn it cytotoxic; (ii) and the poor sintering ability makes the fabrication of porous three-dimensional (3D) scaffolds difficult. All of these relevant features strongly depend on a number of interrelated factors that need to be well compromised. The selected chemical composition strongly determines the glass structure, the biocompatibility, the degradation rate, and the ease of processing (scaffolds fabrication and sintering). This manuscript presents a first general appraisal of the scientific output in the interrelated areas of bioactive glasses and glass-ceramics, scaffolds, implant coatings, and tissue engineering. Then, it gives an overview of the critical issues that need to be considered when developing bioactive glasses for healthcare applications. The aim is to provide knowledge-based tools towards guiding young researchers in the design of new bioactive glass compositions, taking into account the desired functional properties.
Source: Materials
DOI: 10.3390/ma11122530
Institutions: University of Aveiro, National Institute of Materials Physics
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,137
Funders: Michael Reese Health Trust, University of Pennsylvania, Ohio State University, University of Missouri, University of Connecticut, Wenzhou Medical University, University of Missouri-Kansas City, Amrita Vishwa Vidyapeetham University, Munzur Üniversitesi, Universidade Federal do ABC, Newcastle University, University of Leeds, Nanyang Technological University, University of Sydney, Monash University, Radboud Universiteit, Semmelweis Egyetem, Dankook University, Pukyong National University, Amirkabir University of Technology, Universidad Complutense de Madrid, Consejo Nacional de Investigaciones Científicas y Técnicas, Ministerio de Economía y Competitividad, University of Hong Kong, Shanghai Normal University, Gottfried Wilhelm Leibniz Universität Hannover, Universiti Malaya, Politechnika Warszawska, University of Tehran, Universidad de Murcia, Zhejiang University, Shahrekord University, Universidad de Buenos Aires, Universitat de Barcelona, Aristotle University of Thessaloniki, Iran University of Science and Technology, Wuhan University, Second Military Medical University, Urmia University, Fourth Military Medical University, Akademia Górniczo-Hutnicza im. Stanislawa Staszica, Tarbiat Modares University, National Institute of Technology Rourkela, Universidade do Minho, Changhai Hospital of Shanghai, Universidade Estadual Paulista, Southern Medical University, State Key Laboratory of Bioreactor Engineering, Harbin Normal University, Chinese People’s Liberation Army, Centro de Investigação em Materiais Cerâmicos e Compósitos, Leibniz-Gemeinschaft, Fundação para a Ciência e a Tecnologia, National Institute for Materials Science, Universitat Politècnica de València, Division of Materials Research, Lawrence Berkeley National Laboratory
OpenAlex ID: W2905447985