Work

Novel Modified Vaccinia Virus Ankara Vector Expressing Anti-apoptotic Gene B13R Delays Apoptosis and Enhances Humoral Responses

Year: 2018

Type: article

Abstract: MVA is an attractive viral vector for vaccine development due to its safety and immunogenicity in multiple species and humans even under conditions of immunodeficiency. Here, to further improve the immunogenicity of MVA, we developed a novel vector, MVA- B13R , by replacing the fragmented anti-apoptotic genes 181R / 182R with a functional version derived from vaccinia virus, B13R . Our results show that MVA- B13R significantly delays apoptosis in antigen-presenting cells and muscle cells in vitro and augments vaccine-induced humoral immunity in mice, leading to the development of a novel vector for vaccine development against infectious diseases and cancer.

Source: Journal of Virology

DOI: 10.1128/jvi.01648-18

Authors: Lynette S. Chea, Linda S. Wyatt, Sailaja Gangadhara, Bernard Moss, Rama R. Amara

Institutions: Emory University, Emory National Primate Research Center, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: Poxvirus research and outbreaks

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green