Prenatal Household Air Pollution Alters Cord Blood Mononuclear Cell Mitochondrial DNA Copy Number: Sex-Specific Associations
Year: 2018
Type: article
Study design: Clinical Trial
Abstract: Background: Associations between prenatal household air pollution (HAP) exposure or cookstove intervention to reduce HAP and cord blood mononuclear cell (CBMC) mitochondrial deoxyribonucleic acid copy number (mtDNAcn), an oxidative stress biomarker, are unknown. Materials and Methods: Pregnant women were recruited and randomized to one of two cookstove interventions, including a clean-burning liquefied petroleum gas (LPG) stove, or control. Prenatal HAP exposure was determined by serial, personal carbon monoxide (CO) measurements. CBMC mtDNAcn was measured by quantitative polymerase chain reaction. Multivariable linear regression determined associations between prenatal CO and cookstove arm on mtDNAcn. Associations between mtDNAcn and birth outcomes and effect modification by infant sex were explored. Results: LPG users had the lowest CO exposures (p = 0.02 by ANOVA). In boys only, average prenatal CO was inversely associated with mtDNAcn (β = -14.84, SE = 6.41, p = 0.03, per 1ppm increase in CO). When examined by study arm, LPG cookstove had the opposite effect in all children (LPG β = 19.34, SE = 9.72, p = 0.049), but especially boys (β = 30.65, SE = 14.46, p = 0.04), as compared to Control. Increased mtDNAcn was associated with improved birth outcomes. Conclusions: Increased prenatal HAP exposure reduces CBMC mtDNAcn, suggesting cumulative prenatal oxidative stress injury. An LPG stove intervention may reverse this effect. Boys appear most susceptible.
Institutions: Kintampo Health Research Centre, Ghana Health Service, Columbia University, University of Health and Allied Sciences, National Institutes of Health, Fogarty International Center, Beth Israel Deaconess Medical Center, Lamont-Doherty Earth Observatory, Boston University, Icahn School of Medicine at Mount Sinai
Language: English
Subfield: Pollution
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,016
Awards: Household air pollution in Tanzania, placental health and pregnancy outcome, Circulating microRNAs in extracellular vesicles, household air pollution and lung development in Ghana, G4695235992, Prenatal PM2.5 and programming of respiratory outcomes: Placental biomarkers and effect modification by stress, Intervening to Improve Birth Weight and Infant Respiratory Health in Rural Ghana, G9000142336, Child Lung Development Following a Cookstove Intervention: Evidence from GRAPHS, Center for Environmental Health in Northern Manhattan
OpenAlex ID: W2905611033