Work

Cu-Catalyzed Oxidation of C2 and C3 Alkyl-Substituted Indole via Acyl Nitroso Reagents

Year: 2018

Type: article

Abstract: The selective oxidation of C2-alkyl-substituted indoles to 3-oxindole and the selective C-H oxygenation or amination of C2,C3-dialkyl-substituted indoles at C2 are reported under mild conditions. The position of the alkyl substitution on the indole directs the reaction to different pathways under similar conditions.

Source: Organic Letters

DOI: 10.1021/acs.orglett.8b03185

Authors: Jun Zhang, Saeedeh Torabi Kohlbouni, Babak Borhan

Institution: Michigan State University

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: G1495357881, Predicted Reaction Discovery and Application of Catalytic Asymmetric Alkene Halogenations