Work

Haemophilus-Dominant Nasopharyngeal Microbiota Is Associated With Delayed Clearance of Respiratory Syncytial Virus in Infants Hospitalized for Bronchiolitis

Year: 2018

Type: article

Study design: Observational Study

Abstract: The relation of nasopharyngeal microbiota to the clearance of respiratory syncytial virus (RSV) in infants hospitalized for bronchiolitis is not known. In a multicenter cohort, we found that 106 of 557 infants (19%) hospitalized with RSV bronchiolitis had the same RSV subtype 3 weeks later (ie, delayed clearance of RSV). Using 16S ribosomal RNA gene sequencing and a clustering approach, infants with a Haemophilus-dominant microbiota profile at hospitalization were more likely than those with a mixed profile to have delayed clearance, after adjustment for 11 factors, including viral load. Nasopharyngeal microbiota composition is associated with delayed RSV clearance.

Source: The Journal of Infectious Diseases

DOI: 10.1093/infdis/jiy741

Authors: Jonathan M Mansbach, Kohei Hasegawa, Pedro A Piedra, Vasanthi Avadhanula, Joseph F Petrosino, Ashley F Sullivan, Janice A Espinola, Carlos A Camargo

Institutions: Boston Children's Hospital, Harvard University, Massachusetts General Hospital, Baylor College of Medicine

Language: English

Topic: Respiratory viral infections research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Gilead Sciences, Regeneron Pharmaceuticals, Ablynx, Novavax, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases

Awards: Airway dual-transcriptomics in bronchiolitis and risk of asthma: MARC-35 cohort, G1693785127, G1789255991, G2157090909, Nasal microRNA during bronchiolitis and age 6y asthma phenotypes: MARC-35 cohort, G2333309238, Cytokines & transcriptomes in rhinovirus bronchiolitis and risk of incident asthma, G3222093166, G3800109519, G4769286335, Infant specific-IgE, rhinovirus-C bronchiolitis, and incident asthma in MARC-35, G7111521673, G8869719469, G9000004953, G9000010796, G9000059539, G9000073910

OpenAlex ID: W2906147116

FWCI: 3.234

Cites: 15

Cited by: 45

Related to: 10