Work

Immune responses in cardiac repair and regeneration: a comparative point of view

Year: 2018

Type: article

Abstract: Immediately after cardiac injury, the immune system plays major roles in repair and regeneration as it becomes involved in a number of processes including damage-associated signaling, inflammation, revascularization, cardiomyocyte dedifferentiation and replenishment, and fibrotic scar formation/resolution. Recent studies have revealed that different immune responses occur in the various experimental models capable or incapable of cardiac regeneration, and that harnessing these immune responses might improve cardiac repair. In light of this concept, this review analyzes current knowledge about the immune responses to cardiac injury from a comparative perspective. Insights gained from such comparative analyses may provide ways to modulate the immune response as a potential therapeutic strategy for cardiac disease.

Source: Cellular and Molecular Life Sciences

DOI: 10.1007/s00018-018-2995-5

Authors: Shih-Lei Lai, Rubén Marín-Juez, Didier Y. R. Stainier

Institutions: Institute of Biomedical Sciences, Academia Sinica, Max Planck Institute for Heart and Lung Research, Academia Sinica

Language: English

Topic: Congenital heart defects research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,290