Year: 2016
Type: article
Abstract: Inflammatory response represents one of the first immune processes following injury.However, evidence indicates that inflammatory response can also induce cellular protection associated in with preconditioning, a phenomenon in which brief episodes of a sublethal insult induce robust protection against subsequent lethal injuries.The elucidation of mechanisms that allow inflammatory response to confer cellular protection is critical to developing new therapeutic strategies against acute ischemic insults.In the present review, we will give a short overview on a novel zinc-finger protein, MCPIP (also known as Zc3h12a or Regnase-1), which may function as a master integrator of endogenous cellular protection exerted by preconditioning.
Author: Pappachan Kolattukudy
Institution: University of Central Florida
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funder: National Institutes of Health
Award: G9000097073
OpenAlex ID: W2906335464