Work

MSH2 Gene Point Mutations Are Not Antifungal Resistance Markers in Candida glabrata

Year: 2018

Type: article

Study design: Observational Study

Abstract: The high rates of antifungal resistance in Candida glabrata may be facilitated by the presence of alterations in the MSH2 gene. We aimed to study the sequence of the MSH2 gene in 124 invasive C. glabrata isolates causing incident episodes of candidemia ( n = 81), subsequent candidemia episodes ( n = 9), endocarditis ( n = 2), and in vitro -generated echinocandin-resistant isolates ( n = 32) and assessed its relationship with genotypes, acquisition of antifungal resistance in vivo and in vitro , and patient prognosis.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01876-18

Authors: María Ángeles Bordallo-Cardona, Caroline Agnelli, Ana Gómez-Nuñez, Carlos Sánchez-Carrillo, Emilio Bouza, Patricia Muñoz, Pilar Escribano, Jesús Guinea

Institutions: Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense de Madrid, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Centro de Investigación Biomédica en Red

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Instituto de Investigación Sanitaria Gregorio Marañón, Instituto de Salud Carlos III, European Regional Development Fund

Awards: G1075404386, CARACTERIZACIÓN GENOTÍPICA DE CANDIDA COMO HERRAMIENTA MICROBIOLÓGICA PARA LA DISCRIMINACIÓN ENTRE CEPAS INVASORAS O COLONIZADORAS, G3342503300, G3559709381, G3858562445, G4193446334, G4303554532, G5213316532, Impacto clínico de la integración de la triada compuesta por datos de farmacocinética, farmacodinamia, y patogenicidad de Candida en el pronóstico del paciente con candidemia, G7437212214, G7907025313

OpenAlex ID: W2906341356

FWCI: 2.821

Cites: 31

Cited by: 29

Related to: 10