Liquid Chromatography-Tandem Mass Spectrometry Assays for Therapeutic Drug Monitoring of Cefepime
Year: 2018
Type: article
Abstract: With the development and growth of multi-drug resistance organisms, therapeutic drug monitoring (TDM) has become an increasingly common tool to assure the efficacy and safety of antimicrobial therapy. The requirement for TDM has not routinely extended to cephalosporins, such as cefepime, due to their wide therapeutic window. However, the implementation of TDM for cefepime is becoming increasingly important as many Gram-negative bacteria have adapted mechanisms that increase resistance to antimicrobials and therefore require higher concentrations of cefepime for bacterial eradication. Additionally, pharmacokinetic variability and difficulty in treating patients, especially those who are critically ill or those with renal dysfunction, necessitate TDM to ensure optimal cefepime concentrations. \nThis review aims to assess and evaluate the techniques currently utilized to quantify cefepime in both plasma and serum in terms of usefulness for feasible and readily adaptable bedside cefepime TDM.
Source: Journal of Applied Bioanalysis
DOI: 10.17145/jab.18.019
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $517
OpenAlex ID: W2906363410