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Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease

Year: 2018
Type: review
Abstract: Embryonic and postnatal life depend on the uninterrupted function of cardiac muscle cells. These cells, termed cardiomyocytes, display many fascinating behaviors, including complex morphogenic movements, interactions with other cell types of the heart, persistent contractility and quiescence after birth. Each of these behaviors depends on complex interactions between both cardiac-restricted and widely expressed transcription factors, as well as on epigenetic modifications. Here, we review recent advances in our understanding of the genetic and epigenetic control of cardiomyocyte differentiation and proliferation during heart development, regeneration and disease. We focus on those regulators that are required for both heart development and disease, and highlight the regenerative principles that might be manipulated to restore function to the injured adult heart.
Source: Development
DOI: 10.1242/dev.171983
Language: English
Open Access status: green
Funders: Welch Foundation, Fondation Leducq, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G5968285356, G662211534, Chemically assisted remodeling of infarcted heart tissue by targeting Wnt lipidation, Molecular Dissection of Myoblast Fusion In Muscle Development and Regeneration, Deciphering the role of a novel micropeptide in cardiac function and dysfunction, Myoediting of Duchenne muscular dystrophy
OpenAlex ID: W2906576036
FWCI: 0.833
Cites: 155
Cited by: 93
Related to: 10